Who Is Spravato® For? Understanding Treatment-Resistant Depression
Not all depression responds to standard medications. For some people, even after trying multiple antidepressants, symptoms remain. This is known as treatment-resistant depression (TRD), and it affects millions of adults worldwide. If you’ve been asking who is Spravato® for, this article explains the criteria, what TRD means, and why Spravato may be an option.
What Is Treatment-Resistant Depression?
Depression is considered “treatment-resistant” when at least two different antidepressants have been tried at the right dose and duration without significant improvement. People with TRD often continue to experience:
Persistent sadness or hopelessness
Loss of interest in daily activities
Fatigue or lack of motivation
Difficulty concentrating
Disrupted sleep patterns
TRD can be particularly challenging because it reduces quality of life and can leave patients feeling as though nothing will help. That’s why FDA-approved options like Spravato® are important.
Who May Be Eligible for Spravato®?
Spravato® is indicated for adults with treatment-resistant depression. It may be appropriate if you:
Have been diagnosed with major depressive disorder (MDD).
Have tried at least two oral antidepressants without sufficient improvement.
Continue to experience symptoms despite ongoing treatment.
Are under the care of a provider who can determine if Spravato is suitable.
Spravato is always prescribed alongside an oral antidepressant and administered only in a certified medical clinic under supervision.
Who May Not Be a Candidate?
Spravato is not right for everyone. It may not be recommended for people with certain medical conditions, uncontrolled blood pressure, or a history of substance misuse. Pregnant or breastfeeding individuals should also consult closely with their doctor. Only a licensed healthcare provider can determine eligibility.
Why This Matters
Knowing who Spravato is for helps set clear expectations. Spravato is not a first-line treatment — but it is an important, FDA-approved option for people living with TRD who have struggled to find relief. For those patients, it may provide a much-needed alternative and renewed hope for recovery.
