What to Expect During a Spravato® Treatment Session

Starting a new therapy can feel overwhelming, especially if you’re not sure what the process involves. If you’ve been researching Spravato® treatment sessions and wondering what the experience is like, this guide walks you through the step-by-step process so you can feel more prepared.

Before the Session

Spravato® is only administered in a certified medical clinic. Patients do not take the medication home. Before beginning treatment, your healthcare provider will review your medical history, current medications, and ensure Spravato is appropriate for you.

Most patients begin with two sessions per week for the first month, with frequency tapering down over time based on progress.

During the Session

A typical Spravato session lasts about two hours from start to finish. Here’s what to expect:

  1. Check-In – Upon arrival, patients are checked in and may have vital signs recorded, such as blood pressure.

  2. Administration – The patient self-administers Spravato as a nasal spray under the guidance of a clinician. Dosing is carefully monitored to ensure safety.

  3. Monitoring – After administration, patients remain in a comfortable setting for about two hours. During this time, healthcare providers observe for any side effects, such as dizziness, nausea, or drowsiness. Patients can relax, listen to music, or rest quietly.

  4. Discharge – Once monitoring is complete and the care team confirms stability, patients are discharged from the clinic.

After the Session

Because Spravato can cause temporary side effects like drowsiness or slowed reaction time, patients are not allowed to drive after treatment. It’s essential to arrange for a ride home with a friend, family member, or transportation service.

Many patients report feeling tired following a session, so planning for rest afterward can be helpful.

Tips for a Comfortable Experience

  • Bring comfort items like headphones, a book, or calming music to pass the time during monitoring.

  • Eat lightly beforehand to reduce nausea.

  • Plan downtime after the session since you may feel fatigued.

  • Stay consistent with your appointments, as Spravato works best when the schedule is followed.

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Who Is Spravato® For? Understanding Treatment-Resistant Depression